Acetylcholinesterase inhibitory activity of spices and culinary herbs.

Abstract

Cholinesterases play an important role in the area of neurobiology, toxicology, and pharmacology, out of which acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are vital in nerve impulse transmission [1]. The enzyme AChE catalyzes the hydrolysis of the ester bond of acetylcholine to terminate the nerve impulse transmission at the cholinergic synapses [2]. Compounds that are capable of suppressing the activity of AChE are known as AChE inhibitors or anticholinesterases. Anticholinesterases inhibit AChE enzyme, thereby ......